RBC deformation analyzing within capillary blood flow using FSI method

نویسنده

  • Pedram Tehrani
چکیده

The purpose of this study is to investigate the behavior of red blood cells in order to pass through capillaries. In this research, the behavior of a single and multiple red blood cells are numerically investigated using a fluid-structure interaction (FSI) method. For calculations and comparisons of the deformation, displacements and stresses, four object points were selected and two different boundary conditions were applied to the problem. In the first, uniform velocity flow was applied at the inlet of the capillary and in the second model, the oscillating pressure was set. Through these investigations, the result reveals that the deformation in triple configuration of RBCs is more essential, sine the presence of the two additional cells above and beneath the original cell, will change the regime of flow and add extra amount to turbulency. By noticing this fact, in the uniform velocity flow pattern the results are expectable and convincing, because the displacement of triple array is greater than the single shape. But in the oscillating pressure pattern, there is no significant difference between the displacements of two corresponding points at two configurations. This output is in contrast with the results of uniform velocity flow and real situations. It shows that the assumption of uniform velocity flow at the beginning of the capillary is more logical than the oscillating pressure.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

SPH-DEM approach to numerically simulate the deformation of three-dimensional RBCs in non-uniform capillaries

BACKGROUND Blood continuously flows through the blood vessels in the human body. When blood flows through the smallest blood vessels, red blood cells (RBCs) in the blood exhibit various types of motion and deformed shapes. Computational modelling techniques can be used to successfully predict the behaviour of the RBCs in capillaries. In this study, we report the application of a meshfree partic...

متن کامل

Alterations in Red Blood Cell Deformability during Storage: A Microfluidic Approach

Red blood cells (RBCs) undergo extensive deformation when travelling through the microcapillaries. Deformability, the combined result of properties of the membrane-cytoskeleton complex, the surface area-to-volume ratio, and the hemoglobin content, is a critical determinant of capillary blood flow. During blood bank storage and in many pathophysiological conditions, RBC morphology changes, which...

متن کامل

Tension of red blood cell membrane in simple shear flow.

When a red blood cell (RBC) is subjected to an external flow, it is deformed by the hydrodynamic forces acting on its membrane. The resulting elastic tensions in the membrane play a key role in mechanotransduction and govern its rupture in the case of hemolysis. In this study, we analyze the motion and deformation of an RBC in a simple shear flow and the resulting elastic tensions on the membra...

متن کامل

Sepsis impairs microvascular autoregulation and delays capillary response within hypoxic capillaries

INTRODUCTION The microcirculation supplies oxygen (O2) and nutrients to all cells with the red blood cell (RBC) acting as both a deliverer and sensor of O2. In sepsis, a proinflammatory disease with microvascular complications, small blood vessel alterations are associated with multi-organ dysfunction and poor septic patient outcome. We hypothesized that microvascular autoregulation-existing at...

متن کامل

Capillary penetration failure of blood suspensions.

Blood suspension fails to penetrate a capillary with radius R less than 50 microm even if the capillary is perfectly wettable. This invasion threshold is attributed to three red blood cells (RBCs) segregation mechanisms--corner deflection at the entrance, the intermediate deformation-induced radial migration and shear-induced diffusion within a packed slug at the meniscus. The shear-induced rad...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016